NCT03700905 | DrugSheet

Study of Nivolumab Alone or in Combination With Ipilimumab as Immunotherapy vs Standard Follow-up in Surgical Resectable HNSCC After Adjuvant Therapy (IMSTAR-HN) The safety and scientific validity of

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The IMSTAR-HN study compares neoadjuvant N and N ± I 6 months after adjuvant therapy versus standard therapy as first-line treatment for LA-HNSCC. Eligible patients have treatment-naive LA-HNSCC, East

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Study of Nivolumab Alone or in Combination With Ipilimumab as Immunotherapy vs Standard Follow-up in Surgical Resectable HNSCC After Adjuvant Therapy - No Study Results Posted.

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Study NCT03700905 Submitted Date: October 8, 2018 (v1) Study Identification. Unique Protocol ID: CA209-934 : Brief Title: Study of Nivolumab Alone or in Combination With Ipilimumab as Immunotherapy vs

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Surgically treated locally advanced head and neck squamous cell carcinoma often requires postoperative chemoradiation with high risk of acute and late toxicity. DFS after 2 years is approximately 70%.

Tên miền: www.mycancergenome.org Đọc thêm

NCT03700905, CA209-934: Conditions. Head and Neck Cancer. Treatments. Surgical resection of primary tumor, Adjuvant radio(-chemo)therapy, Neoadjuvant Nivolumab, Adjuvant Nivolumab, Adjuvant Nivolumab

Tên miền: www.smartpatients.com Đọc thêm

NCT03700905: EU: 1+3: Post-operative radio(-chemo) therapy 56-66 Gy + chemotherapy cisplatin 100 mg/m 2 on days 1, 22, 43: Nivolumab neoadjuvant within 2 weeks before surgery 3 mg/kg IV on day 1, ever

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Inclusion Criteria: Informed of the investigational nature of this study and give written informed consent; Histologically or cytologically confirmed nasopharyngeal carcinoma, tumor staged as IVB (acc

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Clinical trial for head and neck cancer , Study of Nivolumab Alone or in Combination With Ipilimumab as Immunotherapy vs Standard Follow-up in Surgical Resectable HNSCC After Adjuvant Therapy

Tên miền: www.centerwatch.com Đọc thêm

Jul 1, 2022Introduction. Squamous cell carcinoma of the head and neck (HNSCC) is one of the most common malignancies in the world, accounting for over 90% of head and neck tumors in Asia and Europe []

Tên miền: www.sciencedirect.com Đọc thêm

NCT03700905: Phase 3: Interventional: No Results: Posted: 2018-10-09: Start: 2018-08-21: Results: None: Primary: None: Complete: None: Brief Summary: Multicenter randomized controlled phase III study

Tên miền: drugsheet.com Đọc thêm

Sep 9, 2020Another phase 3 clinical study, IMSTAR-HN (NCT03700905) is evaluating the potential of nivolumab, alone or in combination with ipilimumab, as immunotherapy vs standard follow up in surgical

Tên miền: www.researchgate.net Đọc thêm

TPS6095 Background: Surgically treated locally advanced head and neck squamous cell carcinoma (LA HNSCC) often requires postoperative chemoradiation with high risk of acute and late toxicity. Disease-

Tên miền: ascopubs.org Đọc thêm

Nov 26, 2020Antibody Structure. B-lymphocyte cells are instructed by numerous immunogens, such as bacteria, viruses, fungi, parasites, cellular antigens, chemicals, and synthetic substances to differe

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Abstract. Cancer immunotherapies utilizing immune checkpoint inhibitors (ICI) have demonstrated durable efficacy in a proportion of patients with advanced/metastatic cancers. More recently, the use of

Tên miền: aacrjournals.org Đọc thêm

The pairing of radiotherapy with ICI is currently being tested in a variety of settings across a range of solid tumour types (NCT02239900, NCT03700905, NCT03867175 and NCT03693014).

Tên miền: www.nature.com Đọc thêm

Mar 3, 2021Main text. About 90% of head and neck cancers occur as head and neck squamous cell carcinoma (HNSCC). According to the global cancer statistics of 2018,1 more than 830,000 new HNSCC cases a

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Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston, MA, United States. Frontiers in Oncology , 01 Jan 2020, 10: 608772. DOI: 10.3389/fonc.2

Tên miền: europepmc.org Đọc thêm

Changing Paradigms in Head and Neck Cancer. Head and neck squamous cell carcinoma (HNSCC), which includes cancers of the oral cavity, oropharynx, and larynx/hypopharynx, is the sixth most incident can

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Mar 5, 2021Preclinical data suggest that head and neck squamous cell carcinomas (HNSCC) may evade immune surveillance and induce immunosuppression. One mechanism of immune evasion involves the express

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